Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 3/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15584249 | 0.86 | MERTK (0.53) | MERTKAURKASYKCDK1CDK4 | |
| SCHEMBL653706 | 0.77 | SYK (0.72) | AURKASYKCDK1CDK4CDK2 | |
| SCHEMBL302034 | 0.76 | JAK2 (0.52) | AURKASYKBRD4HDAC1JAK1 | |
| SCHEMBL19675865 | 0.76 | AURKA (0.66) | AURKASYKCDK4CDK2STK17A | |
| SCHEMBL301785 | 0.75 | AURKA (0.57) | AURKASYKCDK4CDK2STK17A | |
| SCHEMBL19676002 | 0.75 | MAPT (0.54) | AURKASYKALDH1A1 | |
| SCHEMBL305410 | 0.75 | SYK (0.59) | AURKASYKCDK1BRD4HDAC1 | |
| SCHEMBL13943297 | 0.74 | SHMT2 (0.82) | SHMT2ALDH1A1 | |
| SCHEMBL14622293 | 0.74 | JAK3 (0.51) | AURKASYKCDK1CDK4CDK2 | |
| SCHEMBL29695653 | 0.73 | STK17A (0.60) | MERTKAURKASYKCDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2840080-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF | FUJIFILM CORP (JP) | 2017-12-06 | — | — | EP | disclosed |