Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28481059 | 0.86 | GRM4 (0.52) | GRM4EGFRTGFBR1ABCB1ABCC1 | |
| SCHEMBL16012778 | 0.84 | EGFR (0.55) | GRM4EGFRTGFBR1ABCB1ABCC1 | |
| SCHEMBL655954 | 0.84 | GRM4 (0.50) | GRM4EGFRTGFBR1ABCB1ABCC1 | |
| SCHEMBL15585196 | 0.84 | GRM4 (0.50) | GRM4EGFRTGFBR1ABCB1ABCC1 | |
| SCHEMBL2627259 | 0.80 | MAPK8 (0.52) | GRM4EGFRNPC1POLBMAPT | |
| SCHEMBL16012092 | 0.79 | PIN1 (0.64) | GRM4EGFRABCG2NPC1POLB | |
| SCHEMBL2627260 | 0.79 | SYK (0.57) | MAPTMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL264886 | 0.77 | GRM4 (0.48) | GRM4EGFRMEN1KMT2ASYK | |
| SCHEMBL265799 | 0.77 | STK17A (0.53) | GRM4EGFRMEN1KMT2ASYK | |
| SCHEMBL30306442 | 0.77 | STK17A (0.53) | GRM4EGFRMEN1KMT2ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2840080-B1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OR SALT THEREOF | FUJIFILM CORP (JP) | 2017-12-06 | — | — | EP | disclosed |