Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 16/20 | 0.50 |
| ▸ | KDM5C | P41229 | 10/20 | 0.50 |
| ▸ | KDM5A | P29375 | 7/20 | 0.50 |
| ▸ | KDM4A | O75164 | 4/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.50 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.49 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.49 |
| ▸ | KDM4B | O94953 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20024591 | 0.83 | KDM5B (0.43) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL22214937 | 0.82 | TSHR (0.45) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL18415056 | 0.76 | CYP1A2 (0.61) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL24690842 | 0.76 | PKM (0.46) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL12831873 | 0.76 | SMN1; SMN2 (0.59) | TSHRNPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL12640033 | 0.75 | CYP1A2 (0.42) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL26862991 | 0.75 | KDM5B (0.58) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL22005801 | 0.74 | KDM5C (0.55) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL29129147 | 0.74 | KDM5B (0.60) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL6637823 | 0.73 | TSHR (0.47) | KDM5BKDM5CKDM4AKDM4CKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |