Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 20/20 | 0.60 |
| ▸ | DRD3 | P35462 | 9/20 | 0.60 |
| ▸ | HTR2A | P28223 | 17/20 | 0.58 |
| ▸ | HTR1A | P08908 | 13/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3781721 | 1.00 | DRD2 (0.60) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL3112221 | 0.89 | DRD2 (0.55) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL3112228 | 0.89 | DRD2 (0.55) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL1967397 | 0.88 | DRD3 (0.60) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL1967395 | 0.88 | DRD3 (0.60) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL14748255 | 0.88 | DRD3 (0.67) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL3453816 | 0.88 | DRD3 (0.67) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL1969324 | 0.88 | DRD3 (0.67) | DRD2DRD3HTR2AHTR1A | |
| SCHEMBL10164205 | 0.86 | HTR2A (0.62) | DRD2DRD3HTR2A | |
| SCHEMBL21729945 | 0.85 | DRD2 (0.69) | DRD2DRD3HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334657-B1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | HOFFMANN LA ROCHE (CH) | 2013-03-06 | — | — | EP | disclosed |
| EP-2334657-A1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-06-22 | — | — | EP | disclosed |
| US-7858630-B2 | D3 and 5-HT2A receptor modulators | HOFFMANN-LA ROCHE INC. (US) | 2010-12-28 | — | — | US | disclosed |
| WO-2010031735-A1 | PIPERAZINE D3 AND 5-HT2A RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-03-25 | — | — | WO | disclosed |