Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 20/20 | 0.76 |
| ▸ | FLT3 | P36888 | 2/20 | 0.70 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17785213 | 0.93 | IRAK4 (0.80) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL17785198 | 0.93 | IRAK4 (0.81) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL22835560 | 0.92 | IRAK4 (0.75) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL17785215 | 0.91 | IRAK4 (0.80) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL17785227 | 0.91 | IRAK4 (0.78) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL17785208 | 0.90 | IRAK4 (0.81) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL17792723 | 0.89 | IRAK4 (0.61) | IRAK4FLT3IRAK1 | |
| SCHEMBL21194960 | 0.88 | IRAK4 (0.76) | IRAK4FLT3IRAK1KCNH2 | |
| SCHEMBL16845781 | 0.88 | IRAK4 (0.74) | IRAK4FLT3 | |
| SCHEMBL19539040 | 0.87 | IRAK4 (0.71) | IRAK4FLT3IRAK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10308634-B2 | Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2019-06-04 | — | — | US | disclosed |
| US-20170349570-A1 | NEW SUBSTITUTED INDAZOLES, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAID NEW SUBSTITUTED INDAZOLES, AND USE OF SAID NEW SUBSTITUTED INDAZOLES TO PRODUCE DRUGS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-12-07 | — | — | US | disclosed |
| US-20170349570-A1 | NEW SUBSTITUTED INDAZOLES, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAID NEW SUBSTITUTED INDAZOLES, AND USE OF SAID NEW SUBSTITUTED INDAZOLES TO PRODUCE DRUGS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308634-B2 | Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs | CYP11B2, CYP11B1, CYP19A1 | IRAK4 230/4885FLT3 1133/4885IRAK1 511/4885 |
| US-20170349570-A1 | NEW SUBSTITUTED INDAZOLES, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS THAT CONTAIN SAID NEW SUBSTITUTED INDAZOLES, AND USE OF SAID NEW SUBSTITUTED INDAZOLES TO PRODUCE DRUGS | CYP11B2, CYP11B1, CYP19A1 | IRAK4 232/4885FLT3 1305/4885IRAK1 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.