Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 17/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 14/20 | 0.57 |
| ▸ | HPGD | P15428 | 13/20 | 0.57 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19681051 | 0.88 | KDM4E (0.53) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL19681191 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL19681173 | 0.83 | KDM4E (0.60) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL19681195 | 0.83 | KDM4E (0.49) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL19681030 | 0.82 | KDM4E (0.59) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL19681146 | 0.75 | KDM4E (0.59) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL19681211 | 0.72 | KDM4E (0.81) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL19667649 | 0.69 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL19681006 | 0.69 | KDM4E (0.59) | ALDH1A1KDM4EHSD17B10HPGDMAPT | |
| SCHEMBL19681193 | 0.68 | KDM4E (0.42) | ALDH1A1KDM4EHSD17B10HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10294214-B2 | Positive allosteric modulators of human melanocortin-4 receptor | VANDERBILT UNIVERSITY (US) | 2019-05-21 | — | — | US | disclosed |
| US-20170349571-A1 | POSITIVE ALLOSTERIC MODULATORS OF HUMAN MELANOCORTIN-4 RECEPTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10294214-B2 | Positive allosteric modulators of human melanocortin-4 receptor | MC4R, MC1R, MC3R | ALDH1A1 4735/4885KDM4E 932/4885HSD17B10 4416/4885 |
| US-20170349571-A1 | POSITIVE ALLOSTERIC MODULATORS OF HUMAN MELANOCORTIN-4 RECEPTOR | MC4R, MC1R, MC3R | ALDH1A1 4735/4885KDM4E 932/4885HSD17B10 4416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.