Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27243965 | 0.78 | CYP2A6 (0.39) | GRM4ALDH1A1KMT2ALMNAACHE | |
| SCHEMBL6849732 | 0.75 | HTT (0.38) | GRM4PLAUMAPTALDH1A1CASP6 | |
| SCHEMBL30160405 | 0.75 | CYP1A2 (0.42) | GRM4CYP3A4MAPTALDH1A1HSD17B10 | |
| SCHEMBL8167379 | 0.75 | GRM4 (0.37) | GRM4MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL18769974 | 0.75 | CYP1A2 (0.42) | GRM4CYP3A4MAPTALDH1A1HSD17B10 | |
| SCHEMBL30301874 | 0.75 | HTT (0.38) | GRM4PLAUMAPTALDH1A1CASP6 | |
| SCHEMBL31729204 | 0.75 | HSD17B10 (0.38) | GRM4CYP3A4TSHRMAPTALDH1A1 | |
| SCHEMBL3068849 | 0.73 | CYP3A4 (0.43) | GRM4PLAUCYP3A4TSHRMAPT | |
| SCHEMBL165745 | 0.71 | L3MBTL1 (0.46) | GRM4CYP3A4TSHRMAPTALDH1A1 | |
| SCHEMBL29601221 | 0.71 | L3MBTL1 (0.46) | GRM4CYP3A4TSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3562806-A1 | METHODS FOR THE PREPARATION OF 6-AMINOISOQUINOLINE | Aerie Pharmaceuticals, Inc. (US) | 2019-11-06 | — | — | EP | claimed |
| WO-2018125548-A1 | METHODS FOR THE PREPARATION OF 6-AMINOISOQUINOLINE | AERIE PHARMACEUTICALS, INC. (US) | 2018-07-05 | — | — | WO | claimed |
| WO-2018125548-A1 | METHODS FOR THE PREPARATION OF 6-AMINOISOQUINOLINE | AERIE PHARMACEUTICALS, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
| US-9840468-B1 | Methods for the preparation of 6-aminoisoquinoline | AERIE PHARMACEUTICALS, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-9840468-B1 | Methods for the preparation of 6-aminoisoquinoline | AERIE PHARMACEUTICALS, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-9840468-B1 | Methods for the preparation of 6-aminoisoquinoline | AERIE PHARMACEUTICALS, INC. (US) | 2017-12-12 | — | — | US | disclosed |