Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 18/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462196 | 1.00 | METAP2 (0.51) | METAP2 | |
| SCHEMBL435970 | 1.00 | METAP2 (0.51) | METAP2 | |
| SCHEMBL437375 | 1.00 | METAP2 (0.51) | METAP2 | |
| SCHEMBL462197 | 1.00 | METAP2 (0.51) | METAP2 | |
| SCHEMBL462398 | 1.00 | METAP2 (0.51) | METAP2 | |
| SCHEMBL10284431 | 0.94 | METAP2 (0.51) | METAP2 | |
| SCHEMBL433933 | 0.94 | METAP2 (0.51) | METAP2 | |
| SCHEMBL16289636 | 0.91 | METAP2 (0.43) | METAP2 | |
| SCHEMBL16290077 | 0.91 | METAP2 (0.43) | METAP2 | |
| SCHEMBL436488 | 0.90 | METAP2 (0.60) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9839623-B2 | Tricyclic compounds and methods of making and using same | ZAFGEN, INC. (US) | 2017-12-12 | — | — | US | disclosed |