Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.69 |
| ▸ | CXCR1 | P25024 | 10/20 | 0.66 |
| ▸ | CCR7 | P32248 | 1/20 | 0.66 |
| ▸ | CCR6 | P51684 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30515695 | 0.83 | CXCR2 (0.74) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL19356188 | 0.83 | CXCR2 (0.74) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL20452298 | 0.83 | CXCR2 (0.74) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12262972 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12573315 | 0.82 | CXCR2 (0.85) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12263221 | 0.81 | CXCR2 (0.70) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL19678009 | 0.81 | CXCR2 (0.70) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL13243271 | 0.81 | CXCR2 (0.83) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12262978 | 0.80 | CXCR2 (0.70) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL184744 | 0.79 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10287278-B2 | Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2019-05-14 | — | — | US | disclosed |
| US-20170349575-A1 | NOVEL CHEMOKINE CXCR1 AND CXCR2 RECEPTOR ANTAGONIST COMPOUNDS, AND USE THEREOF IN THE TREATMENT OF CHEMOKINE-MEDIATED PATHOLOGIES | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10287278-B2 | Chemokine CXCR1 and CXCR2 receptor antagonist compounds, and use thereof in the treatment of chemokine-mediated pathologies | CXCR1, CXCR2, CXCR3 | CXCR2 2/4885CXCR1 1/4885CCR7 11/4885 |
| US-20170349575-A1 | NOVEL CHEMOKINE CXCR1 AND CXCR2 RECEPTOR ANTAGONIST COMPOUNDS, AND USE THEREOF IN THE TREATMENT OF CHEMOKINE-MEDIATED PATHOLOGIES | CXCR2, CXCR1, CXCR3 | CXCR2 1/4885CXCR1 2/4885CCR7 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.