Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9911039 | 0.77 | DGAT1 (0.34) | DGAT1AAK1 | |
| SCHEMBL20798991 | 0.74 | KDM5A (0.45) | DGAT1 | |
| SCHEMBL11049763 | 0.73 | KDM5A (0.41) | DGAT1 | |
| SCHEMBL22020577 | 0.72 | CDK8 (0.40) | — | |
| SCHEMBL25486906 | 0.71 | CCNT1 (0.32) | DGAT1 | |
| SCHEMBL23529925 | 0.70 | DGAT1 (0.36) | DGAT1AKT1 | |
| SCHEMBL19175994 | 0.69 | DGAT1 (0.38) | DGAT1AAK1 | |
| SCHEMBL23869471 | 0.69 | CCNT1 (0.39) | DGAT1AAK1AKT1 | |
| SCHEMBL26199687 | 0.69 | TLR7 (0.34) | — | |
| SCHEMBL4569211 | 0.66 | DGAT1 (0.43) | DGAT1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10301280-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2019-05-28 | — | — | US | disclosed |
| US-20170349572-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC. | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10301280-B2 | Compounds and methods for kinase modulation, and indications therefor | KIT, PRKCH, PRKACA | DGAT1 4286/4885AAK1 380/4885AKT1 42/4885 |
| US-20170349572-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | KIT, PRKCH, PRKACA | DGAT1 4286/4885AAK1 380/4885AKT1 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.