Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.40 |
| ▸ | SYK | P43405 | 5/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683694 | 0.89 | JAK2 (0.46) | JAK2SYKBRD4JAK1HDAC1 | |
| SCHEMBL19683782 | 0.88 | EGFR (0.45) | JAK2SYKEGFRERBB2AURKA | |
| SCHEMBL20878968 | 0.84 | SRC (0.44) | HDAC1FLT3JAK3EGFRERBB2 | |
| SCHEMBL19683791 | 0.81 | EPHX2 (0.40) | JAK2SYKEGFRERBB2BTK | |
| SCHEMBL20878929 | 0.80 | RET (0.53) | RETFLT3KDRAURKABTK | |
| SCHEMBL19683816 | 0.80 | EGFR (0.42) | RETFLT3EGFRERBB2KDR | |
| SCHEMBL20878890 | 0.80 | BRD4 (0.45) | JAK2SYKBRD4JAK1HDAC1 | |
| SCHEMBL20878982 | 0.80 | SMN1; SMN2 (0.45) | JAK2SYKBRD4JAK1HDAC1 | |
| SCHEMBL20878942 | 0.79 | EGFR (0.45) | SYKRETFLT3EGFRERBB2 | |
| SCHEMBL20878986 | 0.79 | EGFR (0.47) | SYKRETEGFRERBB2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |