Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 9/20 | 0.43 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 5/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683715 | 0.92 | RAF1 (0.59) | RAF1RETBRAFFLT3NTRK1 | |
| SCHEMBL19683697 | 0.88 | RET (0.44) | RAF1RETBRAFFLT3NTRK1 | |
| SCHEMBL19683646 | 0.86 | RET (0.40) | RAF1RETBRAFFLT3NTRK1 | |
| SCHEMBL23047310 | 0.86 | RET (0.41) | RAF1RETBRAFFLT3NTRK1 | |
| SCHEMBL20878909 | 0.86 | RET (0.45) | RAF1RETBRAFFLT3NTRK1 | |
| SCHEMBL19683706 | 0.86 | RET (0.41) | RAF1RETBRAFFLT3NTRK1 | |
| SCHEMBL23047347 | 0.84 | RAF1 (0.48) | RAF1RETBRAFFLT3MAPK13 | |
| SCHEMBL23047345 | 0.84 | RET (0.46) | RAF1RETBRAFFLT3NTRK1 | |
| SCHEMBL19683650 | 0.82 | RET (0.38) | RAF1RETBRAFFLT3NTRK1 | |
| SCHEMBL19683696 | 0.82 | FLT3 (0.59) | RAF1RETBRAFFLT3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017206962-A1 | NOVEL INHIBITOR FOR FLT3 KINASE AND USES THEREOF | 合肥中科普瑞昇生物医药科技有限公司 | 2017-12-07 | — | — | WO | disclosed |