Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 15/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19683697 | 0.92 | RET (0.44) | RAF1MAPK13MAPK12MAPK11RET | |
| SCHEMBL20878886 | 0.91 | RAF1 (0.64) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL19683648 | 0.85 | LCK (0.45) | BTKRETBRAFFLT3 | |
| SCHEMBL23047310 | 0.85 | RET (0.41) | RAF1MAPK13MAPK12MAPK11RET | |
| SCHEMBL19683646 | 0.85 | RET (0.40) | RAF1MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL19683630 | 0.84 | RAF1 (0.47) | RAF1MAPK13MAPK12MAPK11RET | |
| SCHEMBL19683696 | 0.82 | FLT3 (0.59) | RAF1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL19683701 | 0.82 | FLT3 (0.44) | EGFRBTKRETBRAFFLT3 | |
| SCHEMBL19683762 | 0.81 | RET (0.45) | RAF1MAPK13MAPK12MAPK11RET | |
| SCHEMBL19683650 | 0.81 | RET (0.38) | RAF1MAPK13MAPK12MAPK11EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3466952-B1 | 1-(4-(4-AMINO-3-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL)-PHENYL)-UREA DERIVATIVES AS FLT3 KINASE INHIBITORS FOR TREATING CANCER | PRECEDO PHARMACEUTICALS CO LTD (CN) | 2021-03-03 | — | — | EP | disclosed |