Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 3/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.31 |
| ▸ | BUB1 | O43683 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19679223 | 0.81 | EGFR (0.41) | PARP1PARP10EGFRMRGPRX4PTPN1 | |
| SCHEMBL19684924 | 0.80 | PARP10 (0.41) | PARP1PARP10HSP90AA1HSP90AB1TRPM2 | |
| SCHEMBL19684653 | 0.76 | HRH3 (0.38) | KMT2A | |
| SCHEMBL21593493 | 0.68 | PARP10 (0.44) | PARP1PARP10EGFRPDE4APARP11 | |
| SCHEMBL19684858 | 0.68 | LRRK2 (0.36) | PARP1PARP10TRPM2EGFRPTPN1 | |
| SCHEMBL13178634 | 0.68 | PDE3B (0.44) | PARP1PARP10PDE4APDE4DPDE4B | |
| SCHEMBL18130722 | 0.66 | PARP10 (0.41) | PARP1PARP10HSP90AA1HSP90AB1PARP11 | |
| SCHEMBL19574541 | 0.65 | PARP11 (0.55) | PARP1PARP10PTPN1PARP11MAPT | |
| SCHEMBL7586205 | 0.64 | PARP1 (0.65) | PARP1PARP10TRPM2MRGPRX4PARP11 | |
| SCHEMBL19684895 | 0.63 | FABP6 (0.35) | PDE4APDE4DPDE4BPDE4CMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348313-A1 | SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER INC. (US) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348313-A1 | SUBSTITUTED CARBONUCLEOSIDE DERIVATIVES USEFUL AS ANTICANCER AGENTS | DUT, NCL, TYMP | PARP1 37/4885PARP10 330/4885HSP90AA1 1888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.