Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19639773 | 0.89 | ELANE (0.53) | ELANECYP2C9CYP3A4 | |
| SCHEMBL19639806 | 0.78 | ELANE (0.43) | ELANECYP2C9CYP3A4 | |
| SCHEMBL19639781 | 0.77 | MAPT (0.49) | MAPTADORA1APPTP53POLB | |
| SCHEMBL19639807 | 0.77 | ELANE (0.48) | ELANECYP2C9CYP3A4 | |
| SCHEMBL19639794 | 0.76 | MAPT (0.47) | MAPTADORA1APPTP53POLB | |
| SCHEMBL19639762 | 0.76 | MAPT (0.48) | MAPTADORA1APPTP53POLB | |
| SCHEMBL19639760 | 0.76 | MAPT (0.47) | MAPTADORA1APPTP53POLB | |
| SCHEMBL19640024 | 0.75 | ELANE (0.54) | ELANECYP2C9CYP3A4 | |
| SCHEMBL19639824 | 0.74 | ELANE (0.44) | ELANECYP2C9CYP3A4PDE4D | |
| SCHEMBL19639823 | 0.70 | ALDH1A1 (0.47) | MAPTADORA1APPTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017207432-A1 | NOVEL COMPOUNDS | CHIESI FARMACEUTICI S.P.A. (IT) | 2017-12-07 | — | — | WO | disclosed |