Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 12/20 | 0.70 |
| ▸ | TP53 | P04637 | 8/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | PKLR | P30613 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1969334 | 0.87 | GAA (0.90) | GAATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL15152605 | 0.86 | GAA (0.64) | GAATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL1967109 | 0.85 | GAA (0.70) | GAATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL1966036 | 0.85 | GAA (0.70) | GAATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL1965255 | 0.82 | GAA (0.64) | GAATP53MAPTSMN1; SMN2KDM4E | |
| SCHEMBL1966521 | 0.81 | GAA (0.66) | GAATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL1970623 | 0.81 | GAA (0.58) | GAATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL1970425 | 0.81 | GAA (0.60) | GAATP53MAPTPOLBSMN1; SMN2 | |
| SCHEMBL1967393 | 0.79 | ALOX5 (0.74) | GAASMN1; SMN2KDM4EALDH1A1PKM | |
| SCHEMBL1968549 | 0.78 | ALOX5 (0.77) | GAASMN1; SMN2KDM4EALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334675-A1 | IMIDAZOPYRIDINES AND IMIDAZOPYRIMIDINES AS HIV-I REVERSE TRANSCRIPTASE INHIBITORS | CSIR (ZA) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010032195-A1 | IMIDAZOPYRIDINES AND IMIDAZOPYRIMIDINES AS HIV-I REVERSE TRANSCRIPTASE INHIBITORS | CSIR (ZA) | 2010-03-25 | — | — | WO | disclosed |