SCHEMBL19685822

SCHEMBL19685822

Cc1cn(C)c2ccc(N3c4ccc(F)cc4C4(c5ccccc5Oc5ccccc54)c4cc(F)ccc43)cc2c1=O

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 5/20 0.34
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MGAM O43451 1/20 0.32
GAA P10253 1/20 0.32
SI P14410 1/20 0.32
MGAM2 Q2M2H8 1/20 0.32
THRB P10828 1/20 0.32
RAB9A P51151 1/20 0.31
TP53 P04637 1/20 0.31
CDK2 P24941 2/20 0.31
NR3C2 P08235 1/20 0.31
CCNE2 O96020 1/20 0.31
CDK4 P11802 1/20 0.31
PRKACA P17612 1/20 0.31
PRKACG P22612 1/20 0.31
PRKACB P22694 1/20 0.31
CCND1 P24385 1/20 0.31
CCNE1 P24864 1/20 0.31
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19685917 0.93 ATM (0.34) GSK3BTHRBTP53CDK2NR3C2
SCHEMBL19685821 0.90 TP53 (0.34) ALDH1A1MGAMGAASIMGAM2
SCHEMBL19685819 0.90 MGAM (0.35) ALDH1A1MGAMGAASIMGAM2
SCHEMBL19685875 0.89 SCN2B (0.32) ALDH1A1RAB9ANR3C2
SCHEMBL19686029 0.86 BRD4 (0.32) KDM4EALDH1A1RAB9ANR3C2
SCHEMBL19685915 0.86 BRD4 (0.32) KDM4EALDH1A1RAB9ANR3C2
SCHEMBL19685870 0.83 MAPK8 (0.36) RAB9ANR3C2ATM
SCHEMBL19686118 0.83 PTPN1 (0.35) GSK3BKDM4EALDH1A1NR3C2
SCHEMBL19685865 0.83 TP53 (0.34) RAB9ATP53
SCHEMBL19685864 0.82 EGLN1 (0.31) ALDH1A1MGAMGAASIMGAM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10714693-B2 Polycyclic compound and organic electroluminescence device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2020-07-14 US disclosed
US-20170352817-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) 2017-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10714693-B2 Polycyclic compound and organic electroluminescence device including the same CYC1, CCNA1, CYCS GSK3B 4500/4885KDM4E 1138/4885ALDH1A1 572/4885
US-20170352817-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME CYC1, CCNA1, CYCS GSK3B 4500/4885KDM4E 1138/4885ALDH1A1 572/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.