Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1973706 | 0.83 | HSD11B1 (0.46) | HSD11B1 | |
| SCHEMBL1969635 | 0.83 | HSD11B1 (0.39) | HSD11B1ALDH1A1 | |
| SCHEMBL1973941 | 0.78 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL1973870 | 0.78 | HSD11B1 (0.51) | HSD11B1 | |
| SCHEMBL1983418 | 0.75 | HSD11B1 (0.59) | HSD11B1 | |
| SCHEMBL1972392 | 0.74 | HSD11B1 (0.50) | HSD11B1 | |
| SCHEMBL1967748 | 0.73 | HSD11B1 (0.53) | HSD11B1 | |
| SCHEMBL1968609 | 0.72 | HSD11B1 (0.57) | HSD11B1 | |
| SCHEMBL1967234 | 0.72 | HSD11B1 (0.53) | HSD11B1 | |
| SCHEMBL4451243 | 0.72 | HSD11B1 (0.53) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086939-B8 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2011-06-22 | — | — | EP | disclosed |
| EP-2086939-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008053194-A2 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | WO | disclosed |