Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19665478 | 0.86 | LMNA (0.40) | GAAEGFRCYP1A2HPGDKDM4E | |
| SCHEMBL29802600 | 0.86 | LMNA (0.40) | GAAEGFRCYP1A2HPGDKDM4E | |
| SCHEMBL21385811 | 0.86 | EGFR (0.53) | EGFRCYP1A2CYP3A4CYP2C9USP2 | |
| SCHEMBL19685580 | 0.86 | MAPK9 (0.50) | EGFRCYP1A2MEN1KMT2AUSP2 | |
| SCHEMBL29802291 | 0.85 | LMNA (0.39) | GAAEGFRCYP1A2HPGDKDM4E | |
| SCHEMBL19665766 | 0.85 | LMNA (0.39) | GAAEGFRCYP1A2HPGDKDM4E | |
| SCHEMBL19666502 | 0.85 | FLT3 (0.41) | GAAEGFRCYP1A2MEN1CYP3A4 | |
| SCHEMBL29717615 | 0.85 | FLT3 (0.41) | GAAEGFRCYP1A2MEN1CYP3A4 | |
| SCHEMBL29717531 | 0.85 | EGFR (0.41) | GAAEGFRCYP1A2MEN1KMT2A | |
| SCHEMBL19666426 | 0.85 | EGFR (0.41) | GAAEGFRCYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017210408-A1 | ANIMAL AND HUMAN ANTI-TRYPANOSOMONAL AND ANTI-LEISHMANIA AGENTS | CELGENE CORPORATION (US) | 2017-12-07 | — | — | WO | disclosed |