Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.71 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.67 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.63 |
| ▸ | MPO | P05164 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | NQO2 | P16083 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11935204 | 0.94 | HTR2A (0.64) | HTR2AMTNR1AMTNR1BALDH1A1CYP2D6 | |
| SCHEMBL1970281 | 0.90 | MTNR1A (0.63) | HTR2AMTNR1AMTNR1BALDH1A1CYP2D6 | |
| SCHEMBL13565027 | 0.84 | MTNR1A (0.55) | HTR2AMTNR1AMTNR1BALDH1A1CYP2D6 | |
| SCHEMBL10119675 | 0.84 | MTNR1A (0.58) | HTR2AMTNR1AMTNR1BALDH1A1MEN1 | |
| SCHEMBL1976170 | 0.84 | MTNR1A (0.61) | HTR2AMTNR1AMTNR1BALDH1A1CYP2D6 | |
| SCHEMBL4859324 | 0.83 | KDM4E (0.65) | HTR2AMTNR1AMTNR1BALDH1A1KDM4E | |
| SCHEMBL24451304 | 0.83 | HTR2A (1.00) | HTR2AMTNR1AMTNR1BALDH1A1CYP2D6 | |
| SCHEMBL30183412 | 0.83 | HTR2A (1.00) | HTR2AMTNR1AMTNR1BALDH1A1CYP2D6 | |
| SCHEMBL9019785 | 0.82 | HTR2A (0.82) | HTR2AMTNR1AMTNR1BALDH1A1CYP2D6 | |
| SCHEMBL15482215 | 0.81 | HTR2A (0.53) | HTR2AMTNR1AMTNR1BALDH1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | disclosed |
| EP-2334643-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | Actelion Pharmaceuticals Ltd. (CH) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010044054-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | HCRTR2, HCRTR1, HRH3 | HTR2A 46/4885MTNR1A 23/4885MTNR1B 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.