Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.36 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686883 | 0.86 | KCNN2 (0.36) | KCNN2KCNN3ADORA2AADORA1CYP3A4 | |
| SCHEMBL19687520 | 0.85 | KCNN2 (0.37) | KCNN2KCNN3ADORA2AADORA1CYP3A4 | |
| SCHEMBL19686888 | 0.85 | KCNN2 (0.36) | KCNN2KCNN3ADORA2AADORA1CYP3A4 | |
| SCHEMBL21165991 | 0.79 | KCNN2 (0.46) | KCNN2KCNN3ADORA2AADORA1CYP3A4 | |
| SCHEMBL19686628 | 0.79 | ALDH1A1 (0.42) | KCNN2KCNN3ALDH1A1SLC34A1 | |
| SCHEMBL19686887 | 0.78 | KCNN2 (0.48) | KCNN2KCNN3ADORA2AADORA1NR2F2 | |
| SCHEMBL19687266 | 0.78 | KCNN2 (0.39) | KCNN2KCNN3ADORA2AADORA1CYP3A4 | |
| SCHEMBL19686626 | 0.77 | KCNN2 (0.38) | KCNN2KCNN3ADORA2AADORA1CYP3A4 | |
| SCHEMBL19686886 | 0.76 | PDE2A (0.42) | KCNN2KCNN3ADORA2ACYP3A4CYP2D6 | |
| SCHEMBL19686621 | 0.76 | KCNN2 (0.38) | KCNN2KCNN3NR2F2NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |