Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 10/20 | 0.45 |
| ▸ | IDH2 | P48735 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 3/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NPR3 | P17342 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686878 | 0.89 | IDH1 (0.45) | IDH1IDH2CNR1PRCPMAPK1 | |
| SCHEMBL21143813 | 0.78 | IDH1 (0.41) | IDH1IDH2CNR1MAPK1MAPK3 | |
| SCHEMBL19686885 | 0.78 | IDH1 (0.38) | IDH1IDH2MAPK1 | |
| SCHEMBL21166186 | 0.75 | IDH1 (0.41) | IDH1IDH2CNR1MAPK1 | |
| SCHEMBL31127253 | 0.75 | IDH1 (0.41) | IDH1IDH2CNR1MAPK1 | |
| SCHEMBL21143647 | 0.74 | IDH1 (0.45) | IDH1IDH2CNR1PRCP | |
| SCHEMBL19686875 | 0.73 | IDH1 (0.47) | IDH1IDH2CNR1CCNT1 | |
| SCHEMBL21144001 | 0.72 | IDH1 (0.50) | IDH1IDH2CCNT1 | |
| SCHEMBL31127376 | 0.72 | IDH1 (0.50) | IDH1IDH2CCNT1 | |
| SCHEMBL21143786 | 0.70 | IDH1 (0.46) | IDH1IDH2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |