Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 6/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.30 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686878 | 0.86 | IDH1 (0.45) | IDH1MAPK8ROCK2KDM1AMAPK1 | |
| SCHEMBL19686612 | 0.79 | KCNN2 (0.39) | IDH1KDM1AMAPK1SYK | |
| SCHEMBL19686884 | 0.78 | IDH1 (0.45) | IDH1MAPK1IDH2 | |
| SCHEMBL19687530 | 0.76 | IDH1 (0.40) | IDH1MAPK1IDH2NUDT1 | |
| SCHEMBL19687531 | 0.74 | IDH1 (0.40) | IDH1IDH2NUDT1 | |
| SCHEMBL19686593 | 0.73 | KCNN2 (0.49) | IDH1MAPK1 | |
| SCHEMBL21144424 | 0.73 | KCNN2 (0.49) | IDH1MAPK1 | |
| SCHEMBL21144427 | 0.73 | KCNN2 (0.49) | IDH1MAPK1 | |
| SCHEMBL19687174 | 0.68 | IDH1 (0.39) | IDH1IDH2 | |
| SCHEMBL19687486 | 0.67 | IDH1 (0.39) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |