Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 5/20 | 0.35 |
| ▸ | NOS1 | P29475 | 4/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 2/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19687248 | 0.95 | IDH1 (0.33) | NOS2NOS1NOS3IDH1IDH2 | |
| SCHEMBL19687402 | 0.91 | IDH1 (0.32) | IDH1IDH2 | |
| SCHEMBL19687441 | 0.90 | NAMPT (0.31) | IDH1IDH2 | |
| SCHEMBL19687219 | 0.90 | IDH1 (0.33) | NOS2NOS1NOS3IDH1IDH2 | |
| SCHEMBL21143980 | 0.86 | IDH1 (0.33) | IDH1IDH2 | |
| SCHEMBL19687504 | 0.86 | IDH1 (0.37) | IDH1IDH2 | |
| SCHEMBL31127084 | 0.86 | IDH1 (0.37) | IDH1IDH2 | |
| SCHEMBL31127042 | 0.86 | NOS2 (0.37) | NOS2NOS1NOS3MAPTPOLB | |
| SCHEMBL19686327 | 0.86 | NOS2 (0.37) | NOS2NOS1NOS3MAPTPOLB | |
| SCHEMBL19687401 | 0.85 | IDH1 (0.37) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |