Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 11/20 | 0.39 |
| ▸ | IDH2 | P48735 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19686576 | 0.77 | ADORA2A (0.60) | ADORA2AADORA1 | |
| SCHEMBL19686523 | 0.76 | IDH1 (0.44) | IDH1IDH2 | |
| SCHEMBL31127141 | 0.73 | IDH1 (0.46) | IDH1IDH2ADORA2AMAPK8ADORA1 | |
| SCHEMBL21144238 | 0.73 | IDH1 (0.46) | IDH1IDH2ADORA2AMAPK8ADORA1 | |
| SCHEMBL19687150 | 0.73 | IDH1 (0.39) | IDH1IDH2 | |
| SCHEMBL19687174 | 0.73 | IDH1 (0.39) | IDH1IDH2 | |
| SCHEMBL19687117 | 0.72 | LMNA (0.49) | IDH1IDH2ADORA2AADORA1PDE4A | |
| SCHEMBL19687152 | 0.71 | IDH1 (0.38) | IDH1IDH2 | |
| SCHEMBL19687151 | 0.71 | IDH1 (0.38) | IDH1IDH2 | |
| SCHEMBL19686270 | 0.71 | ADORA2A (0.41) | IDH1IDH2ADORA2AMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |