Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 18/20 | 0.40 |
| ▸ | IDH2 | P48735 | 4/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19687530 | 0.80 | IDH1 (0.40) | IDH1IDH2NUDT1 | |
| SCHEMBL21143818 | 0.75 | IDH1 (0.40) | IDH1IDH2 | |
| SCHEMBL19687529 | 0.75 | KCNN2 (0.45) | IDH1 | |
| SCHEMBL31127030 | 0.75 | KCNN2 (0.45) | IDH1 | |
| SCHEMBL19687486 | 0.74 | IDH1 (0.39) | IDH1IDH2 | |
| SCHEMBL21144213 | 0.74 | IDH1 (0.39) | IDH1IDH2 | |
| SCHEMBL19686885 | 0.74 | IDH1 (0.38) | IDH1IDH2NUDT1 | |
| SCHEMBL19687396 | 0.73 | IDH1 (0.38) | IDH1IDH2 | |
| SCHEMBL19686523 | 0.73 | IDH1 (0.44) | IDH1IDH2 | |
| SCHEMBL18748587 | 0.71 | IDH1 (0.49) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017139697-A9 | BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH HYPERAMMONEMIA | SYNLOGIC, INC. (US) | 2017-12-07 | — | — | WO | disclosed |