Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.56 |
| ▸ | MELK | Q14680 | 1/20 | 0.56 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 4/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23178972 | 0.82 | JAK2 (0.56) | JAK2RPS6KA3MELKSTK24KDM4E | |
| SCHEMBL30219970 | 0.76 | TRPV1 (0.45) | JAK2RPS6KA3MELKSTK24KDM4E | |
| SCHEMBL6798992 | 0.76 | JAK2 (0.61) | JAK2RPS6KA3MELKSTK24KDM4E | |
| SCHEMBL29026813 | 0.75 | CHEK1 (0.43) | JAK2RPS6KA3MELKSTK24KDM4E | |
| SCHEMBL593971 | 0.73 | KDM4E (0.58) | KDM4ESMN1; SMN2HSD17B10MEN1ALDH1A1 | |
| SCHEMBL1536662 | 0.73 | KDM4E (0.57) | KDM4ESMN1; SMN2HSD17B10PARP1MEN1 | |
| SCHEMBL908781 | 0.72 | KDM4E (0.47) | KDM4ESMN1; SMN2HSD17B10PARP1MEN1 | |
| SCHEMBL168637 | 0.72 | JAK2 (0.61) | JAK2RPS6KA3MELKSTK24KDM4E | |
| SCHEMBL11775264 | 0.72 | JAK2 (0.61) | JAK2RPS6KA3MELKSTK24KDM4E | |
| SCHEMBL3117561 | 0.72 | JAK2 (0.61) | JAK2RPS6KA3MELKSTK24KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349602-A1 | PIPERIDINE SUBSTITUTED TRICYCLIC PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | JANSSEN INFECTIOUS DISEASES BVBA (BE) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349602-A1 | PIPERIDINE SUBSTITUTED TRICYCLIC PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV) | ZC3HAV1, MAVS, PIR | JAK2 1834/4885RPS6KA3 3851/4885MELK 1556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.