Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 19/20 | 0.69 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26381733 | 0.94 | MME (0.61) | MMEMMEL1ACE | |
| SCHEMBL19687935 | 0.94 | MME (0.61) | MMEMMEL1ACE | |
| SCHEMBL19788079 | 0.94 | MME (0.71) | MMEMMEL1ACE | |
| SCHEMBL15467615 | 0.94 | MME (0.71) | MMEMMEL1ACE | |
| SCHEMBL19687854 | 0.93 | MME (0.60) | MMEMMEL1ACE | |
| SCHEMBL19788122 | 0.92 | MME (0.65) | MMEMMEL1ACE | |
| SCHEMBL18922298 | 0.92 | MME (0.65) | MMEMMEL1ACE | |
| SCHEMBL15472738 | 0.91 | MME (0.68) | MMEMMEL1ACE | |
| SCHEMBL19788061 | 0.91 | MME (0.68) | MMEMMEL1ACE | |
| SCHEMBL24350779 | 0.90 | MME (0.56) | MMEMMEL1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349574-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170349574-A1 | NEPRILYSIN INHIBITORS | MME, REN, ACE | MME 1/4885MMEL1 240/4885ACE 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.