Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.36 |
| ▸ | CCNC | P24863 | 6/20 | 0.35 |
| ▸ | CDK8 | P49336 | 6/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19689828 | 1.00 | RAF1 (0.36) | RAF1CCNCCDK8TRPV1NPY2R | |
| SCHEMBL19689800 | 0.91 | RAF1 (0.38) | RAF1TRPV1NPY2RCA2CA9 | |
| SCHEMBL17778714 | 0.91 | RAF1 (0.38) | RAF1TRPV1NPY2RCA2CA9 | |
| SCHEMBL17767972 | 0.91 | RAF1 (0.38) | RAF1TRPV1NPY2RCA2CA9 | |
| SCHEMBL19689799 | 0.91 | RAF1 (0.38) | RAF1TRPV1NPY2RCA2CA9 | |
| SCHEMBL19699693 | 0.90 | TRPV1 (0.34) | RAF1CCNCCDK8TRPV1NPY2R | |
| SCHEMBL19706764 | 0.90 | RAF1 (0.37) | RAF1CCNCCDK8NPY2R | |
| SCHEMBL17768099 | 0.90 | RAF1 (0.37) | RAF1CCNCCDK8NPY2R | |
| SCHEMBL19689721 | 0.90 | RAF1 (0.37) | RAF1CCNCCDK8NPY2R | |
| SCHEMBL19689814 | 0.90 | RAF1 (0.37) | RAF1CCNCCDK8NPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | RAF1 2078/4885CCNC 1885/4885CDK8 626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.