Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.31 |
| ▸ | SDHB | P21912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19696704 | 0.84 | DGAT1 (0.36) | DGAT1 | |
| SCHEMBL4063219 | 0.83 | DGAT1 (0.55) | DGAT1 | |
| SCHEMBL27348100 | 0.81 | DGAT1 (0.44) | DGAT1PTGS2PTGS1 | |
| SCHEMBL20752535 | 0.80 | BRD4 (0.30) | — | |
| SCHEMBL19696738 | 0.80 | — | — | |
| SCHEMBL19696753 | 0.77 | DGAT1 (0.38) | DGAT1SDHB | |
| SCHEMBL20169321 | 0.74 | DGAT1 (0.56) | DGAT1PTGS2PTGS1 | |
| SCHEMBL20169375 | 0.72 | DGAT1 (0.52) | DGAT1PTGS2PTGS1 | |
| SCHEMBL20169333 | 0.72 | DGAT1 (0.74) | DGAT1PTGS2PTGS1 | |
| SCHEMBL24828571 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840507-B2 | 5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives useful as inhibitors of beta-secretase (BACE) | JANSSEN PHARMACEUTICA, NV (BE) | 2017-12-12 | — | — | US | disclosed |