Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GLA | P06280 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 4/20 | 0.39 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19697621 | 0.90 | KDM4E (0.51) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL17438045 | 0.90 | KDM4E (0.53) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL16392277 | 0.87 | KDM4E (0.53) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL14742881 | 0.84 | KDM4E (0.70) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL16370471 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL16392319 | 0.84 | KDM4E (0.50) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL9941870 | 0.83 | KDM4E (0.54) | KDM4EALDH1A1GLAGAAHPGD | |
| Hydrochloric Acid SCHEMBL2051833 | 0.82 | KDM4E (0.51) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL19697726 | 0.82 | ALDH1A1 (0.40) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL16370033 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1GLAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017214413-A1 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS | Chrysalis, Inc. (US) | 2017-12-14 | — | — | WO | disclosed |