Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 6/20 | 0.44 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19699605 | 0.93 | MAPK8 (0.43) | MAPK8RIOK2TYK2SCN10AMAP4K1 | |
| SCHEMBL20012077 | 0.88 | MAPK8 (0.43) | MAPK8RIOK2TYK2SCN10AMAP4K1 | |
| SCHEMBL19706492 | 0.85 | MAPK8 (0.46) | MAPK8NUDT1ALDH1A1 | |
| SCHEMBL19699565 | 0.83 | MAPT (0.53) | MAPK8RIOK2TYK2SCN10AMAP4K1 | |
| SCHEMBL19699575 | 0.82 | MAPT (0.39) | MAPK8RIOK2TYK2SCN10AMAP4K1 | |
| SCHEMBL19699578 | 0.82 | MAPT (0.39) | MAPK8RIOK2TYK2SCN10AMAP4K1 | |
| SCHEMBL19699606 | 0.81 | MAPT (0.39) | MAPK8RIOK2NUDT1TYK2SCN10A | |
| SCHEMBL19699544 | 0.79 | MAPK8 (0.41) | MAPK8RIOK2TYK2SCN10AMAP4K1 | |
| SCHEMBL19699465 | 0.79 | MAPK8 (0.41) | MAPK8RIOK2TYK2SCN10AMAP4K1 | |
| SCHEMBL19728670 | 0.78 | RIOK2 (0.48) | RIOK2TYK2MAPTGSK3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | MAPK8 1686/4885RIOK2 2825/4885NUDT1 435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.