Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.61 |
| ▸ | AGTR2 | P50052 | 10/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6006851 | 0.93 | AGTR1 (0.64) | AGTR1AGTR2PPARG | |
| SCHEMBL6005965 | 0.92 | AGTR1 (0.63) | AGTR1AGTR2PPARG | |
| SCHEMBL6006816 | 0.90 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL6006941 | 0.89 | AGTR1 (0.73) | AGTR1AGTR2PPARG | |
| SCHEMBL6005996 | 0.88 | AGTR1 (0.60) | AGTR1AGTR2PPARG | |
| SCHEMBL6005994 | 0.88 | AGTR1 (0.60) | AGTR1AGTR2PPARG | |
| SCHEMBL6008379 | 0.88 | AGTR1 (0.68) | AGTR1AGTR2PPARG | |
| SCHEMBL6007876 | 0.88 | AGTR1 (0.61) | AGTR1AGTR2PPARG | |
| SCHEMBL6008202 | 0.88 | AGTR1 (0.72) | AGTR1AGTR2PPARG | |
| SCHEMBL6005905 | 0.87 | AGTR1 (0.63) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334651-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010011821-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2010-01-28 | — | — | WO | disclosed |