Sugi Predict

Sugi Predict / Compounds / SCHEMBL19700153

SCHEMBL19700153

SCHEMBL19700153

C#CCN(Cc1ccc(C)cc1)c1ccc(NC(=O)OCC)c(N)c1

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KCNQ2 O43526 6/20 0.87
▸ KCNQ4 P56696 6/20 0.71
▸ KCNQ5 Q9NR82 5/20 0.64
▸ CYP1A2 P05177 3/20 0.49
▸ CYP2C8 P10632 1/20 0.49
▸ CYP2B6 P20813 1/20 0.49
▸ KCNQ3 O43525 5/20 0.48
▸ CYP2C9 P11712 2/20 0.46
▸ CYP2C19 P33261 2/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ ABCB11 O95342 1/20 0.39
▸ ESR1 P03372 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ HTR1A P08908 1/20 0.39
▸ ADRA2A P08913 1/20 0.39
▸ ADORA3 P0DMS8 1/20 0.39
▸ CYP2D6 P10635 1/20 0.39
▸ ALOX15 P16050 1/20 0.39
▸ NFKB1 P19838 1/20 0.39
▸ TBXA2R P21731 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15996879 0.93 KCNQ2 (1.00) KCNQ2KCNQ4KCNQ5CYP1A2CYP2C8
SCHEMBL19700186 0.91 KCNQ2 (0.79) KCNQ2KCNQ4KCNQ5CYP1A2CYP2C8
SCHEMBL30741285 0.90 KCNQ2 (0.81) KCNQ2KCNQ4KCNQ5CYP1A2CYP2C8
SCHEMBL19698444 0.90 KCNQ2 (0.81) KCNQ2KCNQ4KCNQ5CYP1A2CYP2C8
SCHEMBL19698445 0.85 KCNQ2 (0.72) KCNQ2KCNQ4KCNQ5CYP1A2CYP2C8
SCHEMBL30741272 0.85 KCNQ2 (0.72) KCNQ2KCNQ4KCNQ5CYP1A2CYP2C8
SCHEMBL19700144 0.84 KCNQ2 (0.63) KCNQ2KCNQ4KCNQ5CYP1A2KCNQ3
SCHEMBL15996931 0.83 KCNQ2 (0.83) KCNQ2KCNQ4KCNQ5CYP1A2CYP2C8
SCHEMBL15996905 0.83 KCNQ4 (1.00) KCNQ2KCNQ4KCNQ5CYP1A2CYP2C8
SCHEMBL16233333 0.82 KCNQ4 (0.86) KCNQ2KCNQ4KCNQ5CYP1A2CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives OCUTERRA THERAPEUTICS, INC. (US) 2024-01-02 — — US disclosed
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives OCUTERRA THERAPEUTICS, INC. (US) 2024-01-02 — — US disclosed
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. 2017-12-14 — — US disclosed
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES SCIFLUOR LIFE SCIENCES, INC. 2017-12-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170355679-A1 FLUORINATED 2-AMINO-4-(SUBSTITUTED AMINO)PHENYL CARBAMATE DERIVATIVES KCNQ2, KCNQ1, KCNQ3 KCNQ2 1/4885KCNQ4 4/4885KCNQ5 7/4885
US-11858900-B2 Fluorinated 2-amino-4-(substituted amino)phenyl carbamate derivatives KCNQ2, KCNQ1, KCNQ3 KCNQ2 1/4885KCNQ4 4/4885KCNQ5 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.