Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 20/20 | 0.48 |
| ▸ | IDH2 | P48735 | 9/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19700755 | 0.89 | ACHE (0.43) | IDH1IDH2 | |
| SCHEMBL22201527 | 0.88 | IDH1 (0.35) | IDH1IDH2 | |
| SCHEMBL19700750 | 0.76 | IDH1 (0.66) | IDH1IDH2 | |
| SCHEMBL22879064 | 0.73 | IDH1 (0.82) | IDH1IDH2 | |
| SCHEMBL22591169 | 0.72 | IDH1 (0.47) | IDH1IDH2 | |
| SCHEMBL25100564 | 0.71 | IDH1 (0.47) | IDH1IDH2 | |
| SCHEMBL22201753 | 0.69 | IDH1 (0.81) | IDH1IDH2 | |
| SCHEMBL22879045 | 0.69 | IDH1 (0.81) | IDH1IDH2 | |
| SCHEMBL22201732 | 0.68 | ACHE (0.41) | IDH1IDH2 | |
| SCHEMBL21399895 | 0.67 | IDH1 (0.83) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464281-B1 | MUTANT IDH1 INHIBITORS | LILLY CO ELI (US) | 2020-07-08 | — | — | EP | disclosed |
| WO-2017213910-A1 | MUTANT IDH1 INHIBITORS | ELI LILLY AND COMPANY (US) | 2017-12-14 | — | — | WO | disclosed |