Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19697958 | 0.89 | PIK3CD (0.42) | PIK3CDMAPK1 | |
| SCHEMBL20676266 | 0.77 | PIK3CD (0.36) | PIK3CDMAPK1 | |
| SCHEMBL22357767 | 0.76 | HTR1A (0.40) | PIK3CDMAPK1 | |
| SCHEMBL19698032 | 0.75 | MAPK1 (0.47) | PIK3CDMAPK1 | |
| SCHEMBL22357772 | 0.73 | PDE9A (0.42) | PIK3CDMAPK1 | |
| SCHEMBL20676295 | 0.73 | PIK3CD (0.42) | PIK3CDMAPK1 | |
| SCHEMBL26997324 | 0.73 | PIK3CD (0.42) | PIK3CDMAPK1 | |
| SCHEMBL26997309 | 0.72 | KDM5A (0.39) | PIK3CD | |
| SCHEMBL21251097 | 0.72 | PIK3CD (0.43) | PIK3CD | |
| SCHEMBL19697984 | 0.72 | PDE9A (0.44) | PIK3CDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023576-B2 | Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170355698-A1 | HETEROARYL SUBSTITUTED PYRROLOTRIAZINE AMINE COMPOUNDS AS PI3K INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023576-B2 | Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors | PIK3R3, PIK3R5, PIK3R1 | PIK3CD 6/4885MAPK1 200/4885 |
| US-20170355698-A1 | HETEROARYL SUBSTITUTED PYRROLOTRIAZINE AMINE COMPOUNDS AS PI3K INHIBITORS | PIK3R3, PIK3R5, PIK3R1 | PIK3CD 6/4885MAPK1 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.