Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19702011 | 0.83 | NOTUM (0.51) | NOTUMCHRNB2CHRNA4CHRNA7HRH3 | |
| SCHEMBL19702015 | 0.81 | NOTUM (0.50) | BPTFNOTUMHRH3 | |
| SCHEMBL25752839 | 0.80 | NOTUM (0.55) | NOTUMHRH3 | |
| SCHEMBL22187756 | 0.79 | NOTUM (0.51) | NOTUMCHRNB2CHRNA4HRH3 | |
| SCHEMBL19711232 | 0.79 | BPTF (0.62) | BPTFNOTUMCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL19702010 | 0.78 | NOTUM (0.50) | NOTUMHRH3 | |
| SCHEMBL19702014 | 0.77 | NOTUM (0.49) | NOTUMHRH3 | |
| SCHEMBL19702012 | 0.77 | NOTUM (0.55) | NOTUMHRH3 | |
| SCHEMBL26498532 | 0.76 | NOTUM (0.55) | NOTUMHRH3 | |
| SCHEMBL27405160 | 0.76 | NOTUM (0.51) | NOTUMHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | BPTF 1193/4885NOTUM 3221/4885CHRNB2 2984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.