Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 15/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19703374 | 0.81 | ACVRL1 (0.37) | ACVRL1PIK3CDTNK2 | |
| SCHEMBL19279742 | 0.79 | PIK3CD (0.38) | ACVRL1PIK3CD | |
| SCHEMBL21199422 | 0.79 | ACVRL1 (0.39) | ACVRL1PIK3CD | |
| SCHEMBL19698013 | 0.79 | PIK3CD (0.35) | ACVRL1PIK3CD | |
| SCHEMBL19280583 | 0.79 | PIK3CD (0.39) | ACVRL1PIK3CD | |
| SCHEMBL19280492 | 0.78 | ACVRL1 (0.41) | ACVRL1 | |
| SCHEMBL14651915 | 0.77 | NTRK1 (0.38) | ACVRL1PIK3CDTNK2 | |
| SCHEMBL19279707 | 0.77 | CSNK2A2 (0.39) | PIK3CD | |
| SCHEMBL21199034 | 0.76 | ACVRL1 (0.34) | ACVRL1PIK3CD | |
| SCHEMBL21199390 | 0.76 | CSNK2A2 (0.40) | ACVRL1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023576-B2 | Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170355698-A1 | HETEROARYL SUBSTITUTED PYRROLOTRIAZINE AMINE COMPOUNDS AS PI3K INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023576-B2 | Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors | PIK3R3, PIK3R5, PIK3R1 | ACVRL1 3003/4885PIK3CD 6/4885TNK2 447/4885 |
| US-20170355698-A1 | HETEROARYL SUBSTITUTED PYRROLOTRIAZINE AMINE COMPOUNDS AS PI3K INHIBITORS | PIK3R3, PIK3R5, PIK3R1 | ACVRL1 3003/4885PIK3CD 6/4885TNK2 447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.