Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 15/20 | 0.58 |
| ▸ | MMP2 | P08253 | 8/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.54 |
| ▸ | MMP13 | P45452 | 3/20 | 0.51 |
| ▸ | CCR1 | P32246 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19709343 | 0.88 | ADAMTS5 (0.59) | ADAMTS5MMP2ADAMTS4ADAM17MMP13 | |
| SCHEMBL21473409 | 0.87 | ADAMTS5 (0.77) | ADAMTS5MMP2ADAMTS4 | |
| SCHEMBL21474467 | 0.85 | ADAMTS5 (0.80) | ADAMTS5MMP2ADAMTS4ADAM17MMP13 | |
| SCHEMBL19691545 | 0.85 | ADAMTS5 (0.80) | ADAMTS5MMP2ADAMTS4ADAM17MMP13 | |
| SCHEMBL23901205 | 0.85 | ADAMTS5 (0.70) | ADAMTS5MMP2ADAMTS4ADAM17MMP13 | |
| SCHEMBL22892257 | 0.83 | ADAMTS5 (0.56) | ADAMTS5MMP2ADAMTS4ADAM17MMP13 | |
| SCHEMBL23901410 | 0.81 | ADAMTS5 (0.67) | ADAMTS5MMP2ADAMTS4ADAM17MMP13 | |
| SCHEMBL23901420 | 0.80 | ADAMTS5 (0.71) | ADAMTS5MMP2ADAMTS4ADAM17MMP13 | |
| SCHEMBL19996688 | 0.80 | ADAMTS5 (0.71) | ADAMTS5MMP2ADAMTS4ADAM17MMP13 | |
| SCHEMBL23901404 | 0.77 | ADAMTS5 (0.71) | ADAMTS5MMP2ADAMTS4ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017211666-A1 | 5-[3-[PIPERAZIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2017-12-14 | — | — | WO | disclosed |