SCHEMBL19712484

SCHEMBL19712484

Cc1c(-c2ccc(N)nc2)c(F)cn2c(=O)c(OC(=O)O)cc(C3CC3)c12

nearest known ligand 0.37

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 9/20 0.37
FEN1 P39748 8/20 0.37
SSTR5 P35346 3/20 0.33
PIK3CA P42336 4/20 0.31
BRD4 O60885 1/20 0.31
KIT P10721 1/20 0.31
MTOR P42345 2/20 0.31
FYN P06241 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19712465 0.92 ALOX5AP (0.35) ALOX5APFEN1SSTR5PIK3CABRD4
SCHEMBL19712517 0.89 TOP2A (0.31)
SCHEMBL12502395 0.87 ALOX5AP (0.38) ALOX5APFEN1MTOR
SCHEMBL19712497 0.87 PIK3CA (0.30) PIK3CA
SCHEMBL12502341 0.85 ALOX5AP (0.37) ALOX5APFEN1SSTR5PIK3CAKIT
SCHEMBL12502474 0.85 ALOX5AP (0.42) ALOX5APFEN1SSTR5PIK3CAKIT
SCHEMBL19712476 0.85 GABRA1 (0.32)
SCHEMBL19712458 0.85 TOP1 (0.32)
Potassium Ion SCHEMBL15261608 0.84 ALOX5AP (0.35) ALOX5APFEN1PIK3CABRD4KIT
Potassium Ion SCHEMBL12502340 0.84 ALOX5AP (0.35) ALOX5APFEN1PIK3CABRD4KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2670410-B1 ANTIMICROBIAL 4-OXOQUINOLIZINES EMERGENT PRODUCT DEV GAITHERSBURG INC (US) 2017-12-20 EP claimed