SCHEMBL19715652

SCHEMBL19715652

C[C@@H]1C[C@H]1CN(C)Cc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.49
LMNA P02545 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
BLM P54132 1/20 0.49
CARM1 Q86X55 1/20 0.47
PRMT6 Q96LA8 1/20 0.47
PRMT8 Q9NR22 1/20 0.47
TSHR P16473 2/20 0.47
USP2 O75604 1/20 0.46
CYP3A4 P08684 1/20 0.46
MAOA P21397 1/20 0.46
MAOB P27338 1/20 0.46
PYCR1 P32322 1/20 0.46
SLC6A4 P31645 1/20 0.45
AOC3 Q16853 1/20 0.44
CXCR3 P49682 2/20 0.43
SIGMAR1 Q99720 1/20 0.43
KDM4E B2RXH2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4533102 1.00 ALDH1A1 (0.49) ALDH1A1LMNASMN1; SMN2BLMCARM1
SCHEMBL7768827 0.79 ALDH1A1 (0.46) ALDH1A1LMNASMN1; SMN2BLMCARM1
SCHEMBL21413769 0.77 CARM1 (0.47) ALDH1A1LMNASMN1; SMN2BLMCARM1
Dibemethine SCHEMBL2139708 0.77 ALDH1A1 (0.67) ALDH1A1LMNASMN1; SMN2BLMCARM1
SCHEMBL14045705 0.77 ALDH1A1 (0.52) ALDH1A1LMNASMN1; SMN2BLMCARM1
SCHEMBL31716232 0.75 CARM1 (0.49) ALDH1A1LMNASMN1; SMN2BLMCARM1
SCHEMBL8283980 0.75 ALDH1A1 (0.46) ALDH1A1LMNASMN1; SMN2BLMCARM1
SCHEMBL3377311 0.75 ALDH1A1 (0.46) ALDH1A1LMNASMN1; SMN2BLMCARM1
SCHEMBL3377314 0.75 ALDH1A1 (0.46) ALDH1A1LMNASMN1; SMN2BLMCARM1
SCHEMBL13824547 0.75 MEN1 (0.46) ALDH1A1LMNATSHRMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250057815-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2025-02-20 US disclosed
US-20230390249-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2023-12-07 US disclosed
US-RE49352-E1 Carbamoyloxymethyl triazole cyclohexyl acids as LPA antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2023-01-03 US disclosed
US-RE49352-E1 Carbamoyloxymethyl triazole cyclohexyl acids as LPA antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2023-01-03 US disclosed
US-20220249443-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2022-08-11 US disclosed
CN-114601830-A Carbamoyloxymethyltriazolylcyclohexanes as LPA antagonists 百时美施贵宝公司 2022-06-10 CN disclosed
CN-109963843-B Carbamoyloxymethyltriazolylcyclohexanes as LPA antagonists 百时美施贵宝公司 2022-03-11 CN disclosed
EP-3666771-B1 LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-09-29 EP disclosed
EP-3666771-B1 LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-09-29 EP disclosed
US-20210244711-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-08-12 US disclosed
US-20200138789-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2020-05-07 US disclosed
US-20200138789-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2020-05-07 US disclosed
EP-3472148-B1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS BRISTOL MYERS SQUIBB CO (US) 2020-03-11 EP disclosed
US-10576062-B2 Carbamoyloxymethyl triazole cyclohexyl acids as LPA antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2020-03-03 US disclosed
US-10576062-B2 Carbamoyloxymethyl triazole cyclohexyl acids as LPA antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2020-03-03 US disclosed
US-20180333395-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS CHENG PETER TAI WAH (US) 2018-11-22 US disclosed
US-10071078-B2 Carbamoyloxymethyl triazole cyclohexyl acids as LPA antagonists BRISTOL-MYERS SQUIBB COMPANY (US) 2018-09-11 US disclosed
US-20170360759-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS SYNGENE INTERNATIONAL LIMITED (IN) 2017-12-21 US disclosed
US-20170360759-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS SYNGENE INTERNATIONAL LIMITED (IN) 2017-12-21 US disclosed
US-20170360759-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS SYNGENE INTERNATIONAL LIMITED (IN) 2017-12-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170360759-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS LPAR3, LPAR1, LPAR2 ALDH1A1 3382/4885LMNA 881/4885SMN1; SMN2 4370/4885
US-20220249443-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS LPAR3, LPAR1, LPAR2 ALDH1A1 3382/4885LMNA 881/4885SMN1; SMN2 4370/4885
US-20210244711-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS LPAR3, LPAR1, LPAR2 ALDH1A1 3382/4885LMNA 881/4885SMN1; SMN2 4370/4885
US-20200138789-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS LPAR3, LPAR1, LPAR2 ALDH1A1 3382/4885LMNA 881/4885SMN1; SMN2 4370/4885
US-20230390249-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS LPAR3, LPAR1, LPAR2 ALDH1A1 3382/4885LMNA 881/4885SMN1; SMN2 4370/4885
US-10576062-B2 Carbamoyloxymethyl triazole cyclohexyl acids as LPA antagonists LPAR3, LPAR1, LPAR2 ALDH1A1 3382/4885LMNA 881/4885SMN1; SMN2 4370/4885
US-20250057815-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS LPAR3, LPAR1, LPAR2 ALDH1A1 3382/4885LMNA 881/4885SMN1; SMN2 4370/4885
US-20180333395-A1 CARBAMOYLOXYMETHYL TRIAZOLE CYCLOHEXYL ACIDS AS LPA ANTAGONISTS LPAR3, LPAR1, LPAR2 ALDH1A1 3382/4885LMNA 881/4885SMN1; SMN2 4370/4885
US-10071078-B2 Carbamoyloxymethyl triazole cyclohexyl acids as LPA antagonists LPAR3, LPAR1, LPAR2 ALDH1A1 3382/4885LMNA 881/4885SMN1; SMN2 4370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.