Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 14/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1973319 | 0.91 | HSD11B1 (0.55) | HSD11B1IDH1 | |
| SCHEMBL4444896 | 0.86 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL1969216 | 0.77 | HSD11B1 (0.56) | HSD11B1 | |
| SCHEMBL1969219 | 0.77 | HSD11B1 (0.56) | HSD11B1 | |
| SCHEMBL12571429 | 0.77 | HSD11B1 (0.56) | HSD11B1 | |
| SCHEMBL4453419 | 0.77 | HSD11B1 (0.57) | HSD11B1IDH1 | |
| SCHEMBL2009631 | 0.74 | HSD11B1 (0.48) | HSD11B1IDH1 | |
| SCHEMBL2009632 | 0.74 | HSD11B1 (0.48) | HSD11B1IDH1 | |
| SCHEMBL2008046 | 0.71 | HSD11B1 (0.61) | HSD11B1IDH1 | |
| SCHEMBL12571420 | 0.71 | HSD11B1 (0.61) | HSD11B1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086939-B8 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2011-06-22 | — | — | EP | disclosed |