Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.57 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GRM5 | P41594 | 2/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12037576 | 0.88 | GRM4 (0.63) | GRM4GRM1NPC1MAPTPKM | |
| SCHEMBL1973785 | 0.88 | GRM4 (0.67) | GRM4GRM1NPC1MAPTPKM | |
| SCHEMBL1975117 | 0.86 | KDR (0.59) | GRM4GRM1NPC1MAPTPKM | |
| SCHEMBL1972704 | 0.86 | GRM4 (0.57) | GRM4GRM1NPC1MAPTPKM | |
| SCHEMBL20990144 | 0.78 | NPC1 (0.67) | GRM4NPC1MAPTPKMHTT | |
| SCHEMBL1973867 | 0.76 | GRM4 (0.73) | GRM4GRM1NPC1MAPTPKM | |
| SCHEMBL1971521 | 0.76 | GRM4 (0.73) | GRM4GRM1NPC1MAPTPKM | |
| SCHEMBL12037581 | 0.75 | GRM4 (0.55) | GRM4GRM1NPC1MAPTPKM | |
| SCHEMBL15614028 | 0.74 | POLB (0.69) | RAB9AMEN1KMT2ASCN2AGAA | |
| SCHEMBL19176361 | 0.74 | ESR1 (0.62) | NPC1MAPTPKMRAB9AESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110318266-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK SHARP & DOHME CORP. | 2011-12-29 | — | — | US | claimed |
| EP-2334181-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | Merck Sharp & Dohme Corp. (US) | 2011-06-22 | — | — | EP | claimed |
| WO-2010033349-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK & CO., INC. (US) | 2010-03-25 | — | — | WO | claimed |
| US-20110318266-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK SHARP & DOHME CORP. | 2011-12-29 | — | — | US | disclosed |
| US-20110318266-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK SHARP & DOHME CORP. | 2011-12-29 | — | — | US | disclosed |
| US-20110318266-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK SHARP & DOHME CORP. | 2011-12-29 | — | — | US | disclosed |
| EP-2334181-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | Merck Sharp & Dohme Corp. (US) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010033349-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK & CO., INC. (US) | 2010-03-25 | — | — | WO | disclosed |
| WO-2010033349-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | MERCK & CO., INC. (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110318266-A1 | PHTHALIMIDE DERIVATIVE METABOTROPIC GLUTAMATE R4 LIGANDS | GRM4, GRIA4, GRM1 | GRM4 1/4885GRM1 3/4885NPC1 2657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.