Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rasagiline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 8/20 | 0.83 |
| ▸ | ACHE | P22303 | 11/20 | 0.83 |
| ▸ | MAOA | P21397 | 7/20 | 0.83 |
| ▸ | BCHE | P06276 | 2/20 | 0.83 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.83 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.83 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.83 |
| ▸ | HTR6 | P50406 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rasagiline SCHEMBL828682 | 1.00 | ACHE (0.83) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL932650 | 0.94 | ACHE (0.83) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL1820428 | 0.92 | ACHE (0.79) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL6120649 | 0.92 | ACHE (0.79) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL933178 | 0.92 | ACHE (0.79) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL12787613 | 0.91 | MAOB (1.00) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL2827373 | 0.91 | MAOB (1.00) | ACHEMAOBMAOABCHEADRA2B | |
| Azilect SCHEMBL29605291 | 0.91 | MAOB (1.00) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL74699 | 0.91 | MAOB (1.00) | ACHEMAOBMAOABCHEADRA2B | |
| Rasagiline SCHEMBL333333 | 0.91 | MAOB (1.00) | ACHEMAOBMAOABCHEADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231582-B1 | PROCESS FOR THE SYNTHESIS OF PROPARGYLATED AMINOINDAN DERIVATIVES | CIPLA LTD (IN) | 2011-06-22 | — | — | EP | disclosed |
| EP-2231582-A1 | PROCESS FOR THE SYNTHESIS OF PROPARGYLATED AMINOINDAN DERIVATIVES | Cipla Limited (IN) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009081148-A1 | PROCESS FOR THE SYNTHESIS OF PROPARGYLATED AMINOINDAN DERIVATIVES | CIPLA LIMITED (IN) | 2009-07-02 | — | — | WO | disclosed |