Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 8/20 | 0.47 |
| ▸ | AKT1 | P31749 | 5/20 | 0.39 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1972518 | 0.87 | AKT2 (0.46) | AKT2AKT1AKT3GSK3BCYP2D6 | |
| SCHEMBL1972284 | 0.81 | AKT2 (0.48) | AKT2LMNAGSK3BCYP2D6RPS6KB1 | |
| SCHEMBL1003154 | 0.80 | AKT2 (0.72) | AKT2AKT1GSK3BCYP2D6CYP2C9 | |
| SCHEMBL1002683 | 0.78 | AKT2 (0.58) | AKT2AKT1GSK3BCYP2D6CYP2C9 | |
| SCHEMBL3917917 | 0.74 | AKT2 (0.87) | AKT2AKT1AKT3GSK3BCYP2D6 | |
| SCHEMBL1000907 | 0.73 | AKT1 (0.60) | AKT2AKT1GSK3B | |
| SCHEMBL3917914 | 0.73 | AKT2 (0.70) | AKT2AKT1AKT3GSK3BCYP2D6 | |
| SCHEMBL3931922 | 0.72 | AKT2 (0.70) | AKT2AKT1AKT3GSK3BCYP2D6 | |
| SCHEMBL6755688 | 0.72 | HTT (0.47) | AKT2LMNAGSK3BRECQL | |
| SCHEMBL1791997 | 0.70 | RECQL (0.66) | AKT2LMNALRRK2RPS6KB1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812004-B1 | ORTHO- CONDENSED PYRIDINE AND PYRIMIDINE DERIVATIVES (E. G. PURINES) AS PROTEIN KINASES INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2011-06-22 | — | — | EP | claimed |