Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 5/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | KDM4B | O94953 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 3/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1972520 | 0.87 | RPS6KB1 (0.63) | AKT2RPS6KB1KDM4AKDM4BKDM5C | |
| SCHEMBL1972282 | 0.81 | AKT2 (0.47) | AKT2RPS6KB1GSK3BLMNACYP2D6 | |
| SCHEMBL1003154 | 0.79 | AKT2 (0.72) | AKT2RPS6KB1GSK3BCYP2D6 | |
| SCHEMBL473295 | 0.79 | RPS6KB1 (0.50) | AKT2RPS6KB1GSK3BFPR2PROKR1 | |
| SCHEMBL1002683 | 0.78 | AKT2 (0.58) | AKT2RPS6KB1GSK3BCYP2D6 | |
| SCHEMBL3931915 | 0.77 | AKT2 (0.67) | AKT2GSK3BHTTLMNAENPP1 | |
| SCHEMBL1899300 | 0.76 | LRRK2 (0.57) | AKT2RPS6KB1GSK3BHTTLMNA | |
| SCHEMBL3917917 | 0.75 | AKT2 (0.87) | AKT2RPS6KB1GSK3BCYP2D6 | |
| SCHEMBL3917914 | 0.74 | AKT2 (0.70) | AKT2RPS6KB1GSK3BCYP2D6 | |
| SCHEMBL3931922 | 0.74 | AKT2 (0.70) | AKT2RPS6KB1GSK3BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812004-B1 | ORTHO- CONDENSED PYRIDINE AND PYRIMIDINE DERIVATIVES (E. G. PURINES) AS PROTEIN KINASES INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2011-06-22 | — | — | EP | claimed |