Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | GRM5 | P41594 | 1/20 | 0.59 |
| ▸ | CLPP | Q16740 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1971547 | 0.91 | GRM5 (0.73) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL1969211 | 0.91 | GRM5 (0.73) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL1971622 | 0.91 | GRM5 (0.73) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL1970438 | 0.86 | GRM5 (0.58) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL1971647 | 0.86 | GRM5 (0.58) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL4094542 | 0.86 | GRM5 (0.65) | HSD11B1NPC1RAB9AALDH1A1TSHR | |
| SCHEMBL1972180 | 0.86 | GRM5 (0.57) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL1969628 | 0.86 | GRM5 (0.57) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL1974720 | 0.84 | HSD11B1 (0.56) | HSD11B1NPC1RAB9AALDH1A1TP53 | |
| SCHEMBL1970071 | 0.84 | HSD11B1 (0.56) | HSD11B1NPC1RAB9AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912979-B1 | PHENYL-{3-(3-(1H-PYRROL-2-YL)-[1,2,4]OXADIAZOL-5-YL]PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2011-06-22 | — | — | EP | disclosed |