Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP5 | P45974 | 4/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19705733 | 0.74 | EGLN1 (0.43) | USP5EGLN1KDM4EMAPK1MAPT | |
| SCHEMBL19725183 | 0.72 | EGLN1 (0.41) | EGLN1KDM4EMAPK1MAPTHIF1A | |
| SCHEMBL19738292 | 0.71 | EGLN1 (0.40) | EGLN1KDM4EMAPK1MAPTHIF1A | |
| SCHEMBL19698929 | 0.71 | EGLN1 (0.43) | USP5EGLN1KDM4EMAPTHIF1A | |
| SCHEMBL23167367 | 0.70 | HDAC6 (0.49) | — | |
| SCHEMBL21783356 | 0.68 | ATM (0.40) | EGLN1KDM4EMAPTHIF1ASLC22A6 | |
| SCHEMBL3374054 | 0.68 | HCAR2 (0.42) | NR1H4KDM4E | |
| SCHEMBL1219671 | 0.67 | KDM4E (0.40) | EGLN1KDM4EMAPK1MAPTHIF1A | |
| SCHEMBL22804207 | 0.66 | EPHX2 (0.59) | EGLN1KDM4EMAPK1MAPTHIF1A | |
| SCHEMBL30449451 | 0.66 | EPHX2 (0.59) | EGLN1KDM4EMAPK1MAPTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3257847-A1 | FXR (NR1H4) MODULATING COMPOUNDS | Gilead Sciences, Inc. (US) | 2017-12-20 | — | — | EP | disclosed |