Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1972456 | 0.87 | HSD11B1 (0.43) | HSD11B1IDH1ALDH1A1 | |
| SCHEMBL1967351 | 0.85 | HSD11B1 (0.61) | HSD11B1 | |
| SCHEMBL1969176 | 0.81 | HSD11B1 (0.61) | HSD11B1 | |
| SCHEMBL1971051 | 0.81 | HSD11B1 (0.61) | HSD11B1 | |
| SCHEMBL1968067 | 0.80 | HSD11B1 (0.51) | HSD11B1IDH1ALDH1A1 | |
| SCHEMBL4447623 | 0.79 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL1969837 | 0.79 | HSD11B1 (0.49) | HSD11B1ALDH1A1 | |
| SCHEMBL1971135 | 0.77 | HSD11B1 (0.53) | HSD11B1 | |
| SCHEMBL1970498 | 0.77 | HSD11B1 (0.41) | HSD11B1ALDH1A1 | |
| SCHEMBL1970361 | 0.76 | HSD11B1 (0.51) | HSD11B1IDH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086939-B8 | PYRIDINE CARBOXAMIDES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2011-06-22 | — | — | EP | disclosed |