Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | FURIN | P09958 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21733093 | 0.84 | EPHX2 (0.49) | PDE3BPDE3APDE10AFURINEPHX2 | |
| SCHEMBL20148075 | 0.82 | FURIN (0.38) | HTR2AHTR2CHTR2BPDE3BPDE3A | |
| SCHEMBL2760245 | 0.78 | PDE3B (0.43) | HTR2AHTR2CHTR2BPDE3BPDE3A | |
| SCHEMBL2737396 | 0.75 | KDM5A (0.45) | HTR2AHTR2CHTR2BPDE3BPDE3A | |
| SCHEMBL21651924 | 0.75 | FURIN (0.40) | HTR2AHTR2CHTR2BPDE3BPDE3A | |
| SCHEMBL29605026 | 0.75 | AVPR1A (0.49) | FURINHCRTR1HCRTR2EPHX2AVPR1A | |
| SCHEMBL20266971 | 0.75 | AVPR1A (0.49) | FURINHCRTR1HCRTR2EPHX2AVPR1A | |
| SCHEMBL1740359 | 0.73 | EPHX2 (0.50) | HTR2AHTR2CHTR2BFURINHCRTR1 | |
| SCHEMBL20158605 | 0.72 | EPHX2 (0.49) | PDE3BPDE3APDE10AFURINEPHX2 | |
| SCHEMBL9596851 | 0.72 | KDM5A (0.50) | HTR2AHTR2CHTR2BFURINHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9957275-B2 | Pyrazolo[1,5-A]pyrimidines for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170362244-A1 | PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362244-A1 | PYRAZOLO[1,5-A]PYRIMIDINES FOR ANTIVIRAL TREATMENT | TYMP, ZC3HAV1, TYMS | HTR2A 4627/4885HTR2C 3916/4885HTR2B 4177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.